TYMS antibody (AA 265-294)

Catalog No. ABIN7873043

This Rabbit Polyclonal antibody specifically detects TYMS in WB, IF, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for TYMS antibody (AA 265-294) (ABIN7873043)

Target: TYMS (Thymidylate Synthetase (TYMS))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TYMS antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TYMS Antibody

Binding Specificity: AA 265-294

Purpose: Thymidylate Synthase Antibody / TYSY

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 265-294 from the human protein was used as the immunogen for the Thymidylate Synthase Antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Thymidylate Synthase antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Thymidylate Synthase antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for TYMS

Target: TYMS (Thymidylate Synthetase (TYMS))

Alternative Name: Thymidylate Synthase

Background: Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs.

UniProt: P04818

Pathways: Mitotic G1-G1/S Phases