RCC2 antibody (AA 266-495)

Catalog No. ABIN7873057

The Rabbit Polyclonal anti-RCC2 antibody (ABIN7873057) specifically detects RCC2 in WB and IHC (p). The antibody is reactive with Zebrafish (Danio rerio) samples.

Quick Overview for RCC2 antibody (AA 266-495) (ABIN7873057)

Target: RCC2 (Regulator of Chromosome Condensation 2 (RCC2))

Reactivity: Zebrafish (Danio rerio)

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RCC2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-RCC2 Antibody

Binding Specificity: AA 266-495

Purpose: Zebrafish Rcc2 Antibody / Protein RCC2 homolog

Purification: Antigen affinity chromatography

Immunogen: E. coli-derived zebrafish Rcc2 recombinant protein (amino acids K266-L495) was used as the immunogen for the Zebrafish Rcc2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal dilution of the Zebrafish Rcc2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Zebrafish Rcc2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for RCC2

Target: RCC2 (Regulator of Chromosome Condensation 2 (RCC2))

Alternative Name: Rcc2

Background: Zebrafish Rcc2, known as regulator of chromosome condensation 2, is a multifunctional protein that plays a role in cell cycle progression, cytoskeletal dynamics, and cellular signaling. It is particularly involved in mitotic events, where it regulates processes related to chromosome condensation and segregation. Rcc2 is also known to interact with small GTP binding proteins such as Rac1, thereby influencing cell migration, adhesion, and actin cytoskeleton organization.

Zebrafish Rcc2 is an ortholog of the human RCC2 protein and shares significant sequence and functional similarity. In both species, Rcc2 functions as part of the chromosomal passenger complex and contributes to the accurate distribution of chromosomes during mitosis. Disruption of Rcc2 function can impair cell division and affect developmental processes, making it a key protein for studies of cell proliferation and morphogenesis.

Research on zebrafish Rcc2 is valuable for understanding its conserved roles in cell cycle regulation and cytoskeletal rearrangements. Zebrafish models allow for the exploration of Rcc2 function during embryogenesis, where rapid and precise cell division is essential for normal development.

Antibodies targeting zebrafish Rcc2 protein are important tools for studying mitosis, cytoskeletal organization, and related signaling pathways. The orthology between zebrafish Rcc2 and human RCC2 supports the use of zebrafish as a model to investigate fundamental mechanisms of cell division and to study pathways that may be altered in diseases such as cancer.

UniProt: Q6NYE2