MUS81 antibody (AA 283-483)

Catalog No. ABIN7873310

This Rabbit Polyclonal antibody specifically detects MUS81 in ELISA and WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for MUS81 antibody (AA 283-483) (ABIN7873310)

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MUS81 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-MUS81 Antibody

Binding Specificity: AA 283-483

Purpose: MUS81 Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids H283-R483) was used as the immunogen for the MUS81 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MUS81 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MUS81 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MUS81

Target: MUS81 (MUS81 Endonuclease Homolog (MUS81))

Alternative Name: MUS81

Background: Crossover junction endonuclease MUS81 is an enzyme that in humans is encoded by the MUS81 gene. This gene encodes a structure-specific endonuclease which belongs to the XPF/MUS81 endonuclease family and plays a critical role in the resolution of recombination intermediates during DNA repair after inter-strand cross-links, replication fork collapse, and DNA double-strand breaks. The encoded protein associates with one of two closely related essential meiotic endonuclease proteins (EME1 or EME2) to form a complex that processes DNA secondary structures. It contains an N-terminal DEAH helicase domain, an excision repair cross complementation group 4 (ERCC4) endonuclease domain, and two tandem C-terminal helix-hairpin-helix domains. Mice with a homozygous knockout of the orthologous gene have significant meiotic defects including the failure to repair a subset of DNA double strand breaks.

UniProt: Q96NY9

Pathways: DNA Damage Repair