Recombinant RBP4 antibody (AA 29-148)

Catalog No. ABIN7873345

The Rabbit Monoclonal anti-RBP4 antibody (Clone RBP4-7045R) (ABIN7873345) specifically detects RBP4 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant RBP4 antibody (AA 29-148) (ABIN7873345)

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RBP4 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RBP4-7045R

Product Details anti-RBP4 Antibody

Binding Specificity: AA 29-148

Purpose: Recombinant Retinol Binding Protein 4 Antibody / RBP4

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 29-148 was used as the immunogen for the recombinant Retinol Binding Protein 4 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the recombinant Retinol Binding Protein 4 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Aliquot the recombinant Retinol Binding Protein 4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for RBP4

Target: RBP4 (Retinol Binding Protein 4, Plasma (RBP4))

Alternative Name: Retinol Binding Protein 4

Background: Retinol (Vitamin A) is transported in the blood bound to its carrier protein, retinol-binding protein (RBP), also designated plasma retinol-binding protein (PRBP) or RBP4. A member of the lipocalin family, RBP conveys retinol from stores in the liver to peripheral tissues. In plasma, RBP binds transthyretin (TTR, formerly called prealbumin) to prevent glomerular filtration of low molecular weight RBP in the kidneys. The stability of this complex holds diagnostic importance because the molar ratio of RBP:TTR provides an indirect way to indicate marginal Vitamin A deficiency. Vitamin A deficiency blocks the secretion of RBP, resulting in defective delivery and supply to epidermal cells. Originally identified solely as a transporter protein, recent studies correlating increased levels of RBP expression in adipose tissue with Insulin resistance have generated research into the possible roles the protein may play in the pathogenesis of type 2 diabetes and obesity.

UniProt: P02753

Pathways: Regulatory RNA Pathways, Positive Regulation of Peptide Hormone Secretion, Carbohydrate Homeostasis, Production of Molecular Mediator of Immune Response