HRS (HRS) (AA 3-777) antibody

Catalog No. ABIN7873552

The Mouse Monoclonal anti-HRS antibody (Clone 4B7E2) (ABIN7873552) specifically detects HRS in WB, IF, FACS and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for HRS (HRS) (AA 3-777) antibody (ABIN7873552)

Target: HRS

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4B7E2

Product Details

Binding Specificity: AA 3-777

Purpose: HGF-regulated tyrosine kinase substrate Antibody / HRS / HGS

Purification: Antigen affinity purified

Immunogen: Recombinant human HGS protein (amino acids R3-D777) was used as the immunogen for the HGF-regulated tyrosine kinase substrate antibody.

Isotype: IgG2a

Application Details

Application Notes: Optimal dilution of the HGF-regulated tyrosine kinase substrate antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the HGF-regulated tyrosine kinase substrate antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details

Target: HRS

Alternative Name: HGF-regulated tyrosine kinase substrate

Background: Hepatocyte growth factor-regulated tyrosine kinase substrate is an enzyme that in humans is encoded by the HGS gene. It is mapped to 17q25.3. The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation.

UniProt: O14964

Pathways: CXCR4-mediated Signaling Events, EGFR Downregulation