CD226 antibody (AA 31-333)

Catalog No. ABIN7873782

The Rabbit Polyclonal anti-CD226 antibody is suitable to detect CD226 in samples from Mouse and Rat. It has been validated for WB, FACS, ELISA and IHC (p).

Quick Overview for CD226 antibody (AA 31-333) (ABIN7873782)

Target: CD226

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CD226 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CD226 Antibody

Binding Specificity: AA 31-333

Purpose: Cd226 Antibody / Dnam-1

Purification: Antigen affinity purified

Immunogen: Recombinant mouse protein (amino acids E31-L333) was used as the immunogen for the Cd226 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Cd226 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Cd226 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CD226

Target: CD226

Alternative Name: Cd226

Background: DNAM 1, also known as CD226, is a receptor expressed by peripheral blood T lymphocytes that is involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T lymphocytes. DNAM 1 is broadly expressed on T cells, NK cells, platelets, monocytes and a subset of B cells. DNAM-1 is also expressed by a subset of CD3 positive thymocytes. This antibody is reported to inhibit T- and NK cell mediated cytotoxicity against tumour cell targets and to block TNF alpha and IFN gamma secretion by alloantigen-specific T-cells.

UniProt: Q8K4F0

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints