MYCN antibody (AA 335-463)

Catalog No. ABIN7874046

The Mouse Monoclonal anti-MYCN antibody is suitable to detect MYCN in samples from Human. It has been validated for ELISA and FACS.

Quick Overview for MYCN antibody (AA 335-463) (ABIN7874046)

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYCN antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: PCRP-MYCN-1A9

Product Details anti-MYCN Antibody

Binding Specificity: AA 335-463

Purpose: MYCN Antibody / n-Myc

Purification: Protein A/G affinity

Immunogen: A recombinant human MYCN protein (within amino acids 335-463) was used as the immunogen for the MYCN antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the MYCN antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the MYCN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for MYCN

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Alternative Name: MYCN

Background: The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

UniProt: P04198