PAPPA antibody (AA 351-523)

Catalog No. ABIN7874246

This Mouse Monoclonal antibody specifically detects PAPPA in IHC (p). It exhibits reactivity toward Human.

Quick Overview for PAPPA antibody (AA 351-523) (ABIN7874246)

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PAPPA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: PAPPA-2718

Product Details anti-PAPPA Antibody

Binding Specificity: AA 351-523

Purpose: PAPP-A Antibody / Pappalysin-1 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 351-523 from the human protein was used as the immunogen for the PAPP-A antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the PAPP-A antibody should be determined by the researcher.
1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the PAPP-A antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for PAPPA

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Alternative Name: PAPP-A

Background: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

UniProt: Q13219