Recombinant PAPPA antibody (AA 351-523)

Catalog No. ABIN7874256

The Rabbit Monoclonal anti-PAPPA antibody is suitable to detect PAPPA in samples from Human. It has been validated for IHC (p).

Quick Overview for Recombinant PAPPA antibody (AA 351-523) (ABIN7874256)

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This PAPPA antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: PAPPA-8804R

Product Details anti-PAPPA Antibody

Binding Specificity: AA 351-523

Purpose: Pappalysin-1 Antibody / PAPPA

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 351-523) from the human protein was used as the immunogen for the Pappalysin-1 antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the Pappalysin-1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the Pappalysin-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PAPPA

Target: PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))

Alternative Name: Pappalysin-1

Background: Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).

UniProt: Q13219