Factor VII antibody (AA 366-466)

Catalog No. ABIN7874351

This Mouse Monoclonal antibody specifically detects Factor VII in ELISA and IHC (p). It exhibits reactivity toward Human.

Quick Overview for Factor VII antibody (AA 366-466) (ABIN7874351)

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Factor VII antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: F7-3516

Product Details anti-Factor VII Antibody

Binding Specificity: AA 366-466

Purpose: F7 Antibody / Factor VII

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 366-466 from the human protein was used as the immunogen for the F7 antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the F7 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the F7 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Factor VII

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Alternative Name: F7

Background: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling