Factor VII antibody (AA 366-466)

Catalog No. ABIN7874359

The Mouse Monoclonal anti-Factor VII antibody (Clone F7-3512) (ABIN7874359) specifically detects Factor VII in ELISA and IHC (p). The antibody is reactive with Human samples.

Quick Overview for Factor VII antibody (AA 366-466) (ABIN7874359)

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Factor VII antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: F7-3512

Product Details anti-Factor VII Antibody

Binding Specificity: AA 366-466

Purpose: Coagulation Factor VII Antibody / F7

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 366-466) from the human protein was used as the immunogen for the Coagulation Factor VII antibody.

Isotype: IgG2, kappa

Application Details

Application Notes: Optimal dilution of the Coagulation Factor VII antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Coagulation Factor VII antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Factor VII

Target: Factor VII (F7) (Coagulation Factor VII (F7))

Alternative Name: Coagulation Factor VII

Background: Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin and Factors X, IX, V and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble Fibrin clots and the promotion of platelet aggregation. Coagulation Factor VII (serum prothrombin conversion accelerator, proconvertin, F7, Factor VII) is a 406 amino acid, vitamin K-dependent, single chain serine protease that is synthesized in the liver and circulates as an inactive precursor. Factor IX A, Factor X A, Factor XII A or Thrombin-mediated proteolytic cleavage of Factor VII at Arg 152-Ile 153 generates Factor VII A, an active serine protease composed of a catalytic heavy chain disulfide linked to a light chain, containing two EGF-like domains. Mutations at the F7 locus that lead to Factor VII deficiencies are generally asymptomatic or phenotypically uncharacterized, with hemorrhagic diathesis occurring at extremely low levels.

UniProt: P08709

Pathways: Response to Growth Hormone Stimulus, Platelet-derived growth Factor Receptor Signaling