PLK2 antibody (AA 375-406)

Catalog No. ABIN7874461

The Rabbit Polyclonal anti-PLK2 antibody (ABIN7874461) specifically detects PLK2 in WB and IHC (p). The antibody is reactive with Human samples.

Quick Overview for PLK2 antibody (AA 375-406) (ABIN7874461)

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLK2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PLK2 Antibody

Binding Specificity: AA 375-406

Purpose: Polo-like kinase 2 Antibody / PLK2 / SNK

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 375-406 from the human protein was used as the immunogen for the Polo-like kinase 2 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Polo-like kinase 2 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Polo-like kinase 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PLK2

Target: PLK2 (Polo-Like Kinase 2 (PLK2))

Alternative Name: Polo-like kinase 2

Background: Plks (polo-like kinases) encode serine/threonine kinases that are closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo-like kinases, which include Plk, Snk (for serum-inducible kinase, also designated Plk2) and Fnk (for FGF-inducible kinase, also designated Plk3 or PRK), play a role in cell proliferation. Plk protein accumulates in the cell during S and G2 phases of the cell cycle, and both protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Snk and Fnk are immediate-early response genes that are first expressed during G1 phase. SNK may play a role in the division of at least some cell types, such as fibroblasts, and could function in embryogenesis, wound healing or neoplasia SNK mRNA is rapidly induced in human lung fibroblasts upon reintroduction of serum following 36 hours of serum deprivation.

UniProt: Q9NYY3