STAR antibody (AA 39-108)

Catalog No. ABIN7874562

The Mouse Monoclonal anti-STAR antibody is suitable to detect STAR in samples from Human. It has been validated for IHC (p).

Quick Overview for STAR antibody (AA 39-108) (ABIN7874562)

Target: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This STAR antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: STAR-3976

Product Details anti-STAR Antibody

Binding Specificity: AA 39-108

Purpose: StAR Antibody / Steroidogenic acute regulatory protein

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 39-108) from the human protein was used as the immunogen for the StAR antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the StAR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the StAR antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for STAR

Target: STAR (Steroidogenic Acute Regulatory Protein (STAR))

Alternative Name: StAR

Background: Steroidogenic Acute Regulatory Protein (STAR) controls the rate-limiting step of steroidegenesis by translocating cholesterol from the outer mitochondrial membrane to the inner membrane where it is later cleaved to pregnenolone. It is primarily present in steroid-producing cells, including Leydig cells in the testis, theca cells and luteal cells in the ovary and adrenal cells in the adrenal cortex. Due to low levels of pregnenolone, seminomas and Leydig cell tumors display no specific STAR staining. Therefore, STAR antibody may assist in differentiating sex cord stromal tumors (SCST), seminomas and embryonal carcinomas.

UniProt: P49675

Pathways: Metabolism of Steroid Hormones and Vitamin D, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis