MMP2 antibody (AA 412-573)

Catalog No. ABIN7874864

This Rabbit Polyclonal antibody specifically detects MMP2 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for MMP2 antibody (AA 412-573) (ABIN7874864)

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MMP2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-MMP2 Antibody

Binding Specificity: AA 412-573

Purpose: Matrix metalloproteinase 2 Antibody / MMP2

Purification: Antigen affinity purified

Immunogen: E. coli-derived recombinant human protein (amino acids E412-N573) was used as the immunogen for the Matrix metalloproteinase 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Matrix metalloproteinase 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Matrix metalloproteinase 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MMP2

Target: MMP2 (Matrix Metalloproteinase 2 (MMP2))

Alternative Name: Matrix metalloproteinase 2

Background: Matrix metalloproteinase-2 (MMP2) is a Type IV collagenase, 72-kD, which is also known as gelatinase and is a member of a group of secreted zinc metalloproteases. The MMP2 gene is 17 kb long with 13 exons varying in size from 110 to 901 bp and 12 introns ranging from 175 to 4,350 bp, located within a region of human chromosome 16q13. In addition, the extra exons encode the amino acids of the fibronectin-like domain which has so far been found in only the 72- and 92- kDa type IV collagenase. MMP2, which has a critical role in the binding of progelatinase A and TIMP4 via the C-terminal hemopexin-like domain (C domain), is functionally associated on the surface of angiogenic blood vessels. Not only is a likely effector of endometrial menstrual breakdown, MMP2 is also effector and regulator of the inflammatory response. Moreover, MMP2 could be helpful in diagnosing Takayasu arteritis.

UniProt: P08253

Pathways: Activation of Innate immune Response