Synaptogyrin 1 antibody (AA 42-233)

Catalog No. ABIN7874917

The Rabbit Polyclonal anti-Synaptogyrin 1 antibody (ABIN7874917) specifically detects Synaptogyrin 1 in WB, ELISA, ICC, IF and FACS. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Synaptogyrin 1 antibody (AA 42-233) (ABIN7874917)

Target: Synaptogyrin 1 (SYNGR1)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Synaptogyrin 1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunocytochemistry (ICC), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-Synaptogyrin 1 Antibody

Binding Specificity: AA 42-233

Purpose: SYNGR1 Antibody / Synaptogyrin 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human Synaptogyrin 1 recombinant protein (Position: S42-Y233) was used as the immunogen for the SYNGR1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the SYNGR1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the SYNGR1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Synaptogyrin 1

Target: Synaptogyrin 1 (SYNGR1)

Alternative Name: SYNGR1

Background: SYNGR1 antibody targets Synaptogyrin 1, an integral membrane protein of synaptic vesicles that modulates neurotransmitter release and vesicle recycling. Encoded by the SYNGR1 gene on chromosome 22q13.1, Synaptogyrin 1 belongs to the synaptogyrin family of small transmembrane proteins highly conserved among vertebrates. It contains four transmembrane domains with both N- and C-termini facing the cytoplasm and interacts with synaptophysin and vesicular transport machinery. Synaptogyrin 1 contributes to the organization of presynaptic vesicle pools and may influence the kinetics of neurotransmitter exocytosis.

Synaptogyrin 1 is abundantly expressed in neurons throughout the central and peripheral nervous systems, particularly within the hippocampus, cortex, and cerebellum. It colocalizes with synaptophysin at presynaptic terminals and has been implicated in modulating short-term synaptic plasticity. Genetic studies suggest that SYNGR1 plays a role in neuropsychiatric conditions including schizophrenia and bipolar disorder, where altered expression affects synaptic connectivity. By maintaining the balance between vesicle docking and endocytosis, Synaptogyrin 1 ensures efficient neurotransmission under repetitive stimulation.

The SYNGR1 antibody is widely used in neuroscience research to identify synaptic vesicles and study presynaptic organization. Immunohistochemical staining with this antibody shows punctate labeling along axons and synaptic terminals, corresponding to vesicle-rich regions. In western blot analysis, Synaptogyrin 1 appears as a 25 kilodalton band. Its high conservation allows cross-reactivity among mammalian species, making the antibody suitable for studies in human, mouse, and rat tissues. By labeling presynaptic vesicles, the SYNGR1 antibody facilitates mapping of synaptic networks and quantitative analysis of synapse density across brain regions.

Beyond basic neuroscience, Synaptogyrin 1 has clinical relevance. Expression profiling in neurodegenerative diseases such as Alzheimer's and Parkinson's reveals synaptic protein loss correlating with disease progression. Reduced SYNGR1 expression has also been linked to cognitive decline and altered synaptic activity in psychiatric disorders. Functionally, Synaptogyrin 1 may influence neurotransmitter transporter trafficking, including those for serotonin and dopamine. The antibody thus supports a broad range of studies spanning molecular synaptic physiology, disease biomarker discovery, and neural circuit mapping. NSJ Bioreagents offers a validated SYNGR1 antibody optimized for its applications, ensuring accurate detection of this essential synaptic vesicle protein.

UniProt: O43759

Pathways: Regulation of long-term Neuronal Synaptic Plasticity