M6PR antibody (AA 424-529)

Catalog No. ABIN7874936

This Mouse Monoclonal antibody specifically detects M6PR in WB and IHC (p). It exhibits reactivity toward Human.

Quick Overview for M6PR antibody (AA 424-529) (ABIN7874936)

Target: M6PR (Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This M6PR antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 6G2

Product Details anti-M6PR Antibody

Binding Specificity: AA 424-529

Purpose: M6PR Antibody / IGF2R

Purification: Affinity purified

Immunogen: An E. coli-derived human protein (amino acids F424-R529) was used as the immunogen for the M6PR antibody.

Isotype: IgG2b

Application Details

Application Notes: Optimal dilution of the M6PR antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the M6PR antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for M6PR

Target: M6PR (Mannose-6-Phosphate Receptor (Cation Dependent) (M6PR))

Alternative Name: M6PR

Background: Insulin-like growth factor 2 receptor, also called IGF2R or I-MPR is a protein that in humans is encoded by the IGF2R gene. This gene is mapped to 6q25.3. This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate, although the binding sites for either are located on different segments of the receptor. This receptor functions in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. While the related mouse gene shows exclusive expression from the maternal allele, imprinting of the human gene appears to be polymorphic, with only a minority of individuals showing expression from the maternal allele.

UniProt: P11717