Dynamin 1-Like antibody (AA 452-736)

Catalog No. ABIN7875098

This Rabbit Polyclonal antibody specifically detects Dynamin 1-Like in WB and ELISA. It exhibits reactivity toward Human and Rat.

Quick Overview for Dynamin 1-Like antibody (AA 452-736) (ABIN7875098)

Target: Dynamin 1-Like (DNM1L)

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Dynamin 1-Like antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Dynamin 1-Like Antibody

Binding Specificity: AA 452-736

Purpose: Dynamin-1-like protein Antibody / DNM1L / DRP1

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids Q452-W736) was used as the immunogen for the Dynamin-1-like protein antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Dynamin-1-like protein antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Dynamin-1-like protein antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Dynamin 1-Like

Target: Dynamin 1-Like (DNM1L)

Alternative Name: Dynamin-1-like protein

Background: Dynamin-1-like protein is a GTPase that regulates mitochondrial fission. In humans, dynamin-1-like protein, which is typically referred to as dynamin-related protein 1 (Drp1), is encoded by the DNM1L gene. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms.

UniProt: O00429