beta Amyloid antibody (AA 500-700)

Catalog No. ABIN7875429

The Mouse Monoclonal anti-beta Amyloid antibody is suitable to detect beta Amyloid in samples from Human. It has been validated for IHC (p).

Quick Overview for beta Amyloid antibody (AA 500-700) (ABIN7875429)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: APP-3667

Product Details anti-beta Amyloid Antibody

Binding Specificity: AA 500-700

Purpose: Amyloid beta Antibody / APP

Purification: Protein A/G affinity

Immunogen: A recombinant fragment (within amino acids 500-700) of human APP protein was used as the immunogen for the Amyloid beta antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Amyloid beta antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Amyloid beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta

Background: Proteolytic cleavage of the Amyloid protein precursor (APP) gives rise to the b-Amyloid and Amyloid A4 proteins, which are present in human platelets. Amyloid deposition is associated with type II diabetes, Down syndrome and a variety of neurological disorders, including Alzheimer s disease. The Amyloid precursor protein (APP) undergoes alternative splicing, resulting in several isoforms. Proteolytic cleavage of APP leads to the formation of the Amyloid b/A4 Amyloid protein. This protein is involved in the formation of neurofibrillary tangles and plaques that characterize the senile plaques of Alzheimer s patients. APLP1 (Amyloid precursor-like protein 1) and APLP2 are structurally similar to APP. Human APLP2 is a membrane-bound sperm protein that contains a region highly homologous to the transmembrane-cytoplasmic domains of APP found in brain plaques of Alzheimer s disease patients.

UniProt: P05067

Pathways: Inflammasome