Glypican 3 antibody (AA 511-580) (CF®555)

Catalog No. ABIN7875532

The CF®555-conjugated Mouse Monoclonal anti-Glypican 3 antibody (Clone SPM595) (ABIN7875532) specifically detects Glypican 3 in FACS and IF. The antibody is reactive with Human samples.

Quick Overview for Glypican 3 antibody (AA 511-580) (CF®555) (ABIN7875532)

Target: Glypican 3 (GPC3)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Glypican 3 antibody is conjugated to CF®555

Application: Flow Cytometry (FACS), Immunofluorescence (IF)

Clone: SPM595

Product Details anti-Glypican 3 Antibody (CF®555)

Binding Specificity: AA 511-580

Purpose: Glypican 3 Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant fragment containing amino acids 511-580 from the human protein was used as the immunogen for the Glypican-3 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Glypican 3 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 500 µL at 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store the Glypican 3 antibody at 2-8oC, protected from light.

Target Details for Glypican 3

Target: Glypican 3 (GPC3)

Alternative Name: Glypican 3

Background: Glypican-3 (GPC3) is a glycosylphospatidyl inositol-anchored membrane protein, which may also be found in a secreted form. Anti-GPC3 has been identified as a useful tumor marker for the diagnosis of hepatocellular carcinoma (HCC), hepatoblastoma, melanoma, testicular germ cell tumors, and Wilms tumor and hepatoblastoma, with a low or undetectable expression in normal adjacent tissue. In patients with thyroid cancer, expression of GPC3 is dramatically enhanced in certain types of cancers: 100 % in follicular carcinoma and 70 % in papillary carcinoma. Expression of GPC3 in follicular carcinoma is significantly higher than that of follicular adenoma. In contrast, GPC3 is not expressed in anaplastic carcinoma.

UniProt: P51654

Pathways: Glycosaminoglycan Metabolic Process