TUSC1 antibody (AA 54-209)

Catalog No. ABIN7875647

This Rabbit Polyclonal antibody specifically detects TUSC1 in WB, ELISA and IP. It exhibits reactivity toward Mouse, Human and Rat.

Quick Overview for TUSC1 antibody (AA 54-209) (ABIN7875647)

Target: TUSC1 (Tumor Suppressor Candidate 1 (TUSC1))

Reactivity: Mouse, Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TUSC1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Product Details anti-TUSC1 Antibody

Binding Specificity: AA 54-209

Purpose: TUSC1 Antibody / Tumor suppressor candidate 1

Purification: Immunogen affinity purified

Immunogen: E.coli-derived human TUSC1 recombinant protein (Position: A54-L209) was used as the immunogen for the TUSC1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the TUSC1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the TUSC1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for TUSC1

Target: TUSC1 (Tumor Suppressor Candidate 1 (TUSC1))

Alternative Name: TUSC1

Background: TUSC1 antibody detects Tumor suppressor candidate 1, encoded by the TUSC1 gene on chromosome 9p21. TUSC1 antibody is widely used to study this protein, originally identified in lung cancer research as part of a genomic region frequently deleted in tumors. Although not fully characterized biochemically, TUSC1 is strongly implicated as a tumor suppressor, participating in cell cycle regulation, apoptosis, and maintenance of genomic stability. Its expression pattern across tissues and frequent inactivation in cancers highlight its importance in normal growth control and oncogenesis.

Structurally, TUSC1 encodes a small cytoplasmic and nuclear protein with predicted coiled-coil regions that may serve as scaffolding modules. These domains suggest potential roles in mediating protein-protein interactions and stabilizing regulatory complexes. Despite lacking enzymatic motifs, TUSC1 likely influences signaling pathways indirectly by modulating the activity of other proteins or transcriptional regulators. Subcellular fractionation studies show that TUSC1 can shuttle between the nucleus and cytoplasm, further broadening its regulatory potential.

Functionally, TUSC1 acts as a negative regulator of cell growth. Studies demonstrate that cells lacking TUSC1 exhibit increased proliferation, while reintroduction suppresses colony formation in vitro and tumor growth in xenograft models. TUSC1 has been associated with activation of apoptotic pathways, possibly by facilitating mitochondrial apoptotic signaling and caspase activation. Its ability to influence both cell cycle and apoptosis highlights its tumor suppressor characteristics. Researchers use TUSC1 antibody to investigate expression changes between normal and malignant tissues, particularly in lung, ovarian, renal, and brain cancers.

Clinically, deletions or reduced expression of TUSC1 are observed in non-small cell lung carcinoma and multiple other tumors. Mechanistically, loss of TUSC1 often occurs through chromosomal deletion of 9p21, a locus that also contains CDKN2A, another tumor suppressor gene. Epigenetic silencing via promoter hypermethylation has been reported, adding another layer of regulation. Clinical studies suggest that TUSC1 status may correlate with prognosis, with low expression linked to more aggressive tumor phenotypes. Restoration of TUSC1 in cancer cell models increases sensitivity to chemotherapy and radiation, highlighting its therapeutic potential.

Beyond oncology, TUSC1 may also influence development and tissue homeostasis. Animal studies show tissue-specific expression during embryogenesis, suggesting developmental roles that remain underexplored. Transcriptomic data indicate potential involvement in neuronal pathways, though further research is needed. These diverse associations make TUSC1 an appealing target for continued study. NSJ Bioreagents supplies TUSC1 antibody as a reliable reagent for cancer research, molecular biology, and developmental studies.

UniProt: Q2TAM9