MERTK antibody (AA 55-148)

Catalog No. ABIN7875683

This Mouse Monoclonal antibody specifically detects MERTK in IHC (p). It exhibits reactivity toward Human.

Quick Overview for MERTK antibody (AA 55-148) (ABIN7875683)

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MERTK antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: MERTK-3015

Product Details anti-MERTK Antibody

Binding Specificity: AA 55-148

Purpose: MerTK Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant human partial protein (amino acids 55-148) was used as the immunogen for the MerTK antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the MerTK antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the MerTK antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MERTK

Target: MERTK (C-Mer Proto-Oncogene Tyrosine Kinase (MERTK))

Alternative Name: MerTK

Background: MerTK, also called c-Mer, is a member of the Mer/Axl/Tyro3 receptor kinase family. It is a 984 residue transmembrane protein made up of one tyrosine kinase domain, two Fibronectin type-III domains and two immunoglobulinlike C2-type domains. MerTK is the mammalian ortholog of the chicken retroviral oncogene product v-Eyk. This protein plays a critical role in macrophage activation, platelet aggregation, clot stability and the efficient removal of apoptotic cells. Specifically, MerTK acts as a signaling molecule, triggering outer segment ingestion in the retinal pigment epithelium (RPE) phagocytic process. Evidence suggests that MerTK signals via interaction with phosphatidylinositol-specific phospholipase C 2). When the gene encoding for MerTK is mutated, the RPE phagocytosis pathway is disrupted and autosomal recessive retinitis pigmentosa (RP) may result, leading to degeneration of retinal photoreceptor cells.

UniProt: Q12866

Pathways: RTK Signaling