RHOBTB2 antibody (AA 554-604)

Catalog No. ABIN7875717

The Mouse Monoclonal anti-RHOBTB2 antibody is suitable to detect RHOBTB2 in samples from Human. It has been validated for IHC (p).

Quick Overview for RHOBTB2 antibody (AA 554-604) (ABIN7875717)

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RHOBTB2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DBC2-3361

Product Details anti-RHOBTB2 Antibody

Binding Specificity: AA 554-604

Purpose: RHOBTB2 Antibody / DBC2

Purification: Protein A/G affinity

Immunogen: A portin of amino acids 554-604 from the human protein was used as the immunogen for the RHOBTB2 antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the RHOBTB2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the RHOBTB2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for RHOBTB2

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Alternative Name: RHOBTB2

Background: The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.

UniProt: Q9BYZ6