RHOBTB2 antibody (AA 554-604)

Catalog No. ABIN7875719

This Mouse Monoclonal antibody specifically detects RHOBTB2 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for RHOBTB2 antibody (AA 554-604) (ABIN7875719)

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RHOBTB2 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: DBC2-3364

Product Details anti-RHOBTB2 Antibody

Binding Specificity: AA 554-604

Purpose: DBC2 Antibody / RHOBTB2

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 554-604 from the human protein was used as the immunogen for the DBC2 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the DBC2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the DBC2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for RHOBTB2

Target: RHOBTB2 (rho-Related BTB Domain Containing 2 (RHOBTB2))

Alternative Name: DBC2

Background: The Rho subfamily of Ras-related GTPases controls multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. DBC-2 (deleted in breast cancer 2 gene protein), also known as RHOBTB2 (Rho-related BTB domain-containing protein 2), is a 727 amino acid member of the RhoBTB subfamily of Rho GTPases. Members of the RhoBTB subfamily are evolutionarily conserved and are characterized by a proline-rich region, a GTPase domain and two tandem BTB repeats. Expressed ubiquitously with highest levels in neural tissue, heart, brain and fetal lung, DBC-2 contains two BTB (POZ) domains through which it may bind to and regulate the function of target proteins, such as CUL-3. Additionally, DBC-2 is thought to function as a regulator of cell cycle and apoptosis events. Under normal conditions, DBC-2 is thought to exhibit tumor suppressor activity. Mutations in the gene encoding DBC-2 are associated with breast cancer, suggesting that mutated DBC-2 may play a role in carcinogenesis.

UniProt: Q9BYZ6