JUP antibody (AA 556-745)

Catalog No. ABIN7875724

The Mouse Monoclonal anti-JUP antibody (Clone 4C12D7) (ABIN7875724) specifically detects JUP in WB, IF, FACS and IHC (p). The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for JUP antibody (AA 556-745) (ABIN7875724)

Target: JUP (Junction Plakoglobin (JUP))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This JUP antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 4C12D7

Product Details anti-JUP Antibody

Binding Specificity: AA 556-745

Purpose: JUP Antibody / Junction Plakoglobin / Gamma Catenin

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids M556-A745) was used as the immunogen for the JUP antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the JUP antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the JUP antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for JUP

Target: JUP (Junction Plakoglobin (JUP))

Alternative Name: JUP

Background: Junction plakoglobin (JUP), also known as gamma-catenin, is a protein that in humans is encoded by the JUP gene. It is a member of the catenin protein family and homologous to g-catenin, and it is mapped to 17q21.2. This gene encodes a major cytoplasmic protein that is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins. Meanwhile, JUP may have distinct roles in Wnt signaling and cancer via differential effects on downstream target genes.

UniProt: P14923

Pathways: Cell-Cell Junction Organization, Maintenance of Protein Location