Recombinant alpha Sarcomeric Actin (AA 557-692) antibody

Catalog No. ABIN7875746

This Rabbit Monoclonal antibody specifically detects alpha Sarcomeric Actin in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant alpha Sarcomeric Actin (AA 557-692) antibody (ABIN7875746)

Target: alpha Sarcomeric Actin

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: ACTN2-7041R

Product Details

Binding Specificity: AA 557-692

Purpose: Recombinant Sarcomeric Alpha Actinin Antibody / Alpha Actinin 2 / ACTN2

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 557-692 from the human protein was used as the immunogen for the recombinant Sarcomeric Alpha Actinin antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Sarcomeric Alpha Actinin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze-thaw cycles

Storage: -20 °C

Storage Comment: Aliquot the recombinant Sarcomeric Alpha Actinin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details

Target: alpha Sarcomeric Actin

Alternative Name: Sarcomeric Alpha Actinin

Background: Alpha actinins belong to the spectrin gene superfamily which represents a diverse group of cytoskeletal proteins, including the alpha and beta spectrins and dystrophins. Alpha actinin is an actin-binding protein with multiple roles in different cell types. In non-muscle cells, the cytoskeletal isoform is found along microfilament bundles and adherens-type junctions, where it is involved in binding actin to the membrane. In contrast, skeletal, cardiac, and smooth muscle isoforms are localized to the Z-disc and analogous dense bodies, where they help anchor the myofibrillar actin filaments. This gene encodes a muscle-specific, alpha actinin isoform that is expressed in both skeletal and cardiac muscles. Several transcript variants encoding different isoforms have been found for this gene.

UniProt: P35609