HBEGF antibody (AA 63-148)

Catalog No. ABIN7876206

The Rabbit Polyclonal anti-HBEGF antibody is suitable to detect HBEGF in samples from Mouse and Rat. It has been validated for WB and ELISA.

Quick Overview for HBEGF antibody (AA 63-148) (ABIN7876206)

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HBEGF antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-HBEGF Antibody

Binding Specificity: AA 63-148

Purpose: Dtr Antibody / Hbegf

Purification: Antigen affinity purified

Immunogen: An E.coli-derived mouse recombinant protein (D63-L148) was used as the immunogen for the Dtr antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Dtr antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Dtr antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for HBEGF

Target: HBEGF (Heparin-Binding EGF-Like Growth Factor (HBEGF))

Alternative Name: Dtr

Background: Heparin-binding EGF-like growth factor (HB-EGF), also called Diphtheria toxin receptor (Dtr) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. Enables epidermal growth factor receptor binding activity, growth factor activity, and heparin binding activity. Involved in positive regulation of keratinocyte migration, positive regulation of smooth muscle cell proliferation, and wound healing, spreading of epidermal cells. Acts upstream of or within several processes, including epidermal growth factor receptor signaling pathway, positive regulation of peptidyl-tyrosine phosphorylation, and regulation of heart contraction. Located in extracellular space. Is integral component of plasma membrane. Is expressed in several structures, including branchial arch, heart, oral region gland, telencephalon, and tooth. Human ortholog(s) of this gene implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. Orthologous to human HBEGF (heparin binding EGF like growth factor).

UniProt: Q06186

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway