NPR3 antibody (AA 67-97)

Catalog No. ABIN7876388

This Mouse Polyclonal antibody specifically detects NPR3 in WB, IF and IHC (p). It exhibits reactivity toward Human.

Quick Overview for NPR3 antibody (AA 67-97) (ABIN7876388)

Target: NPR3 (Atrial Natriuretic Peptide Receptor 3 (NPR3))

Reactivity: Human

Host: Mouse

Clonality: Polyclonal

Conjugate: This NPR3 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NPR3 Antibody

Binding Specificity: AA 67-97

Purpose: Natriuretic peptide receptor C Antibody / NPRC

Immunogen: A portion of amino acids 67-97 from the human protein was used as the immunogen for the Natriuretic peptide receptor C antibody.

Isotype: Ig Fraction

Application Details

Application Notes: Titration of the Natriuretic peptide receptor C antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Natriuretic peptide receptor C antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for NPR3

Target: NPR3 (Atrial Natriuretic Peptide Receptor 3 (NPR3))

Alternative Name: Natriuretic peptide receptor C

Background: Natriuretic peptide receptor C / NPRC is a receptor protein found in various tissues, including the heart, kidney, and blood vessels. Its main function is to bind to natriuretic peptides, which are hormones that help regulate blood pressure and fluid balance. When natriuretic peptides bind to Natriuretic peptide receptor C, they are degraded and their effects are blocked, leading to an increase in blood pressure. Natriuretic peptide receptor C also plays a role in the development of heart failure. Research has shown that increased levels of NPRC in the body can lead to impaired responses to natriuretic peptides, which in turn can contribute to the progression of heart failure. In addition to its role in cardiovascular health, NPRC has also been implicated in other diseases, such as obesity and diabetes. Studies have shown that NPRC levels are elevated in patients with these conditions, suggesting a potential link between Natriuretic peptide receptor C and metabolic disorders.

UniProt: P17342

Pathways: cAMP Metabolic Process