MAEL antibody (AA 73-347)

Catalog No. ABIN7876680

The Rabbit Polyclonal anti-MAEL antibody is suitable to detect MAEL in samples from Human. It has been validated for ELISA, WB and FACS.

Quick Overview for MAEL antibody (AA 73-347) (ABIN7876680)

Target: MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MAEL antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Flow Cytometry (FACS)

Product Details anti-MAEL Antibody

Binding Specificity: AA 73-347

Purpose: MAEL Antibody / Maelstrom homolog

Purification: Antigen affinity purified

Immunogen: An E.coli-derived human recombinant protein (E73-Q347) was used as the immunogen for the MAEL antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the MAEL antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the MAEL antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for MAEL

Target: MAEL (Maelstrom Spermatogenic Transposon Silencer (MAEL))

Alternative Name: MAEL

Background: The mammalian homolog of the Drosophila protein Maelstrom is expressed in the male germline and localizes to the sex body in spermatocytes and the chromatoid body in round spermatids. Similar to its expression in Drosophila, Maelstrom is a component of nuages, a germ-cell specific organelle and is thought to be essential for spermatogenesis and transposon repression during meiosis. In humans, Maelstrom has been found to be expressed only in the testis and in various cancer cell lines. Treatment of these cell lines with the demethylating agent 5'-Aza-2-Deoxycytidine significantly upregulated Maelstrom levels, indicating that its expression is regulated by DNA methylation.

UniProt: Q96JY0