Recombinant INSM1 antibody (AA 81-125)

Catalog No. ABIN7876889

This Mouse Monoclonal antibody specifically detects INSM1 in IHC (p). It exhibits reactivity toward Human.

Quick Overview for Recombinant INSM1 antibody (AA 81-125) (ABIN7876889)

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This INSM1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RINSM1-6287

Product Details anti-INSM1 Antibody

Binding Specificity: AA 81-125

Purpose: INSM1 Antibody / Insulinoma associated protein 1

Purification: Protein A/G affinity

Immunogen: A recombinant partial protein sequence (within amino acids 81-125) from the human protein was used as the immunogen for the INSM1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the INSM1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the INSM1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for INSM1

Target: INSM1 (Insulinoma-Associated 1 (INSM1))

Alternative Name: INSM1

Background: Insulinoma-associated protein 1 (INSM1) is a developmentally regulated zinc-finger transcription factor. It localizes to the nucleus and is expressed in embryonic issues undergoing neuroendocrine differentiation. INSM1 is not expressed in normal adult tissues but can be found highly expressed in neuroendocrine tumors. INSM1 is positive in 95 % of lung small cell carcinoma and 91 % of lung large cell neuroendocrine carcinoma, compared with 75 % and 78 % with the combined panel of traditional neuroendocrine markers (synaptophysin, chromogranin, and CD56). INSM1 stains 100 % of the atypical carcinoids, typical carcinoids and paragangliomas, but only 3 % of adenocarcinomas and 4 % of squamous cell carcinomas. Therefore, INSM1 is sensitive and specific to be a single first-line pan-neuroendocrine marker.

UniProt: Q01101