IRS2 antibody (AA 83-1338)

Catalog No. ABIN7876932

The Rabbit Polyclonal anti-IRS2 antibody is suitable to detect IRS2 in samples from Human and Rat. It has been validated for WB, ELISA and IHC (p).

Quick Overview for IRS2 antibody (AA 83-1338) (ABIN7876932)

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IRS2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-IRS2 Antibody

Binding Specificity: AA 83-1338

Purpose: Insulin receptor substrate 2 Antibody / IRS2

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids R83-E1338) was used as the immunogen for the Insulin receptor substrate 2 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the Insulin receptor substrate 2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the Insulin receptor substrate 2 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for IRS2

Target: IRS2 (Insulin Receptor Substrate 2 (IRS2))

Alternative Name: Insulin receptor substrate 2

Background: Insulin receptor substrate 2 (IRS2) is a protein that in humans is encoded by the IRS2 gene. It is mapped to 13q34. This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. IRS2 is expressed in many cells, it may be essential for signaling by several receptor systems.

UniProt: Q9Y4H2

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Response to Growth Hormone Stimulus, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process