ECSIT antibody (AA 83-339)

Catalog No. ABIN7876939

The Rabbit Polyclonal anti-ECSIT antibody (ABIN7876939) specifically detects ECSIT in WB, ELISA, IHC (p), IF and FACS. The antibody is reactive with Human samples.

Quick Overview for ECSIT antibody (AA 83-339) (ABIN7876939)

Target: ECSIT

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ECSIT antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Flow Cytometry (FACS)

Product Details anti-ECSIT Antibody

Binding Specificity: AA 83-339

Purpose: ECSIT Antibody

Purification: Antigen affinity purified

Immunogen: Recombinant human protein (amino acids E83-S339) was used as the immunogen for the ECSIT antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ECSIT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ECSIT antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for ECSIT

Target: ECSIT

Alternative Name: ECSIT

Background: Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial (ECSIT), also known as SITPEC, is a protein that in humans is encoded by the ECSIT gene. Activation of NF-kB as a result of Toll-like receptor (TLR) and IL-1 receptor signaling is a major component of innate immune responses. Signals from these receptors are relayed by a number of adapter molecules such as TRIF, TIRAP, and MyD88 to kinases such as IRAK and other intermediates such as TNF receptor associated factor (TRAF)-6. ECSIT (evolutionarily conserved signaling intermediate in Toll pathways) was initially identified as a cytoplasmic protein interacting specifically with TNF receptor associated factor (TRAF)-6 in the TLR pathway. Recently however, ECSIT has also been shown to be required for bone morphogenetic protein (Bmp) signaling and mesoderm formation during mouse embryogenesis, indicating the possibility of cross-talk between the TLR/IL-B and Bmp signaling pathways.

UniProt: Q9BQ95

Pathways: TLR Signaling, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome