Recombinant NKX3-1 antibody (AA 92-224)

Catalog No. ABIN7877157

The Mouse Monoclonal anti-NKX3-1 antibody is suitable to detect NKX3-1 in samples from Human. It has been validated for ELISA and IHC (p).

Quick Overview for Recombinant NKX3-1 antibody (AA 92-224) (ABIN7877157)

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NKX3-1 antibody is un-conjugated

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: RNKX3-1-6620

Product Details anti-NKX3-1 Antibody

Binding Specificity: AA 92-224

Purpose: NKX3.1 Antibody (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: A portion of amino acids 92-224 was used as the immunogen for the NKX3.1 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the NKX3.1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the NKX3.1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for NKX3-1

Target: NKX3-1 (NK3 Homeobox 1 (NKX3-1))

Alternative Name: NKX3.1

Background: NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.

UniProt: Q99801

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus