PMCH antibody (AA 94-122)

Catalog No. ABIN7877190

The Rabbit Polyclonal anti-PMCH antibody is suitable to detect PMCH in samples from Human and Mouse. It has been validated for WB, FACS and IHC (p).

Quick Overview for PMCH antibody (AA 94-122) (ABIN7877190)

Target: PMCH (Pro-Melanin-Concentrating Hormone (PMCH))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PMCH antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-PMCH Antibody

Binding Specificity: AA 94-122

Purpose: Pro-MCH Antibody / PMCH

Purification: Antigen affinity purified

Immunogen: A portion of amino acids 94-122 from the human protein was used as the immunogen for the Pro-MCH antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the Pro-MCH antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the Pro-MCH antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for PMCH

Target: PMCH (Pro-Melanin-Concentrating Hormone (PMCH))

Alternative Name: Pro-MCH

Background: The melanin-concentrating hormone (MCH) is a cyclic neuropeptide isolated initially from salmon pituitary gland and later from rat hypothalamus (summarized by Nahon et al., 1992 [PubMed 1572663]). In mammals, MCH perikarya are confined largely to the lateral hypothalamus and zona incerta area with extensive neuronal projections throughout the brain, including the neurohypophysis. The anatomic distribution suggests a neurotransmitter or neuromodulator role for MCH in a broad array of neuronal functions directed toward the regulation of goal-directed behavior, such as food intake, and general arousal. MCH and 2 other putative neuropeptides, NEI and NGE, are encoded by the same precursor and appear colocalized in nerve cells and in many instances within the projections. The precursor is designated pro-melanin-concentrating hormone (PMCH).

UniProt: P20382

Pathways: Carbohydrate Homeostasis, Feeding Behaviour