Filaggrin antibody (AA 998-1104) (Biotin)

Catalog No. ABIN7877301

The Mouse Monoclonal anti-Filaggrin antibody is suitable to detect Filaggrin in samples from Human. It has been validated for IHC (p).

Quick Overview for Filaggrin antibody (AA 998-1104) (Biotin) (ABIN7877301)

Target: Filaggrin (FLG)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Filaggrin antibody is conjugated to Biotin

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: FLG-1563

Product Details anti-Filaggrin Antibody (Biotin)

Binding Specificity: AA 998-1104

Purpose: Filaggrin Antibody

Purification: Protein G affinity chromatography

Immunogen: A portion of amino acids 998-1104 from the human protein was used as the immunogen for the Filaggrin antibody.

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal dilution of the Filaggrin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: 0.1 mg/mL with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Filaggrin antibody at 2-8oC (up to one month) or aliquot and store at -20oC (longer term).

Target Details for Filaggrin

Target: Filaggrin (FLG)

Alternative Name: Filaggrin

Background: Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules. Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.

UniProt: P20930

Pathways: Sensory Perception of Sound, Stem Cell Maintenance