Acetyl-CoA Carboxylase beta antibody (C-Term)

Catalog No. ABIN7877306

This Rabbit Polyclonal antibody specifically detects Acetyl-CoA Carboxylase beta in WB, IHC (p) and FACS. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Acetyl-CoA Carboxylase beta antibody (C-Term) (ABIN7877306)

Target: Acetyl-CoA Carboxylase beta (ACACB)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Acetyl-CoA Carboxylase beta antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Product Details anti-Acetyl-CoA Carboxylase beta Antibody

Binding Specificity: C-Term

Purpose: ACACB Antibody / Acetyl-CoA carboxylase 2

Purification: Antigen affinity

Immunogen: A peptide from the C-terminal region of human Acetyl-CoA carboxylase 2 protein was used as the immunogen for this ACACB antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ACACB antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the ACACB antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for Acetyl-CoA Carboxylase beta

Target: Acetyl-CoA Carboxylase beta (ACACB)

Alternative Name: ACACB

Background: Acetyl-CoA carboxylase 2 also known as ACC-beta or ACC2 is an enzyme that in humans is encoded by the ACACB gene. It is mapped to 12q24.11. Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms.

UniProt: O00763

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process