OGG1 antibody (full length)

Catalog No. ABIN7877599

The Mouse Monoclonal anti-OGG1 antibody (Clone CPTC-OGG1-1) (ABIN7877599) specifically detects OGG1 in IHC (p). The antibody is reactive with Human samples.

Quick Overview for OGG1 antibody (full length) (ABIN7877599)

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OGG1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: CPTC-OGG1-1

Product Details anti-OGG1 Antibody

Binding Specificity: full length

Purpose: OGG1 Antibody / 8-Oxoguanine DNA Glycosylase

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human protein was used as the immunogen for this OGG1 antibody.

Isotype: IgG2c, kappa

Application Details

Application Notes: Optimal dilution of the OGG1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the OGG1 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for OGG1

Target: OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))

Alternative Name: OGG1

Background: 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA, and 8-oxoguanine is the most frequent base lesion. Therefore, formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore, defects in OGG1 may be a cause of renal cell carcinoma.

UniProt: O15527

Pathways: DNA Damage Repair