Cyclin B2 antibody (full length)

Catalog No. ABIN7878064

The Mouse Monoclonal anti-Cyclin B2 antibody (Clone X29-2) (ABIN7878064) specifically detects Cyclin B2 in ELISA. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Cyclin B2 antibody (full length) (ABIN7878064)

Target: Cyclin B2 (CCNB2)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cyclin B2 antibody is un-conjugated

Application: ELISA

Grade: Carrier-free

Clone: X29-2

Product Details anti-Cyclin B2 Antibody

Binding Specificity: full length

Purpose: Cyclin B2 Antibody / CCNB2 (azide and preservative free)

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length Xenopus laevis Cyclin B2 protein was used as the immunogen for this Cyclin B2 antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the Cyclin B2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the Cyclin B2 antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Cyclin B2

Target: Cyclin B2 (CCNB2)

Alternative Name: Cyclin B2

Background: In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.

UniProt: O95067

Pathways: Cell Division Cycle, M Phase