MYCN antibody (full length)

Catalog No. ABIN7878702

The Mouse Monoclonal anti-MYCN antibody is suitable to detect MYCN in samples from Human, Mouse and Rat. It has been validated for WB and IF.

Quick Overview for MYCN antibody (full length) (ABIN7878702)

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This MYCN antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: NMYC-1

Product Details anti-MYCN Antibody

Binding Specificity: full length

Purpose: n-Myc Antibody

Purification: Protein G affinity chromatography

Immunogen: A recombinant full-length human n-Myc protein was used as the immunogen for the n-Myc antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the n-Myc antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the n-Myc antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for MYCN

Target: MYCN (N-Myc Proto-Oncogene Protein (MYCN))

Alternative Name: n-Myc

Background: The v-Myc oncogene, initially identified in the MC29 avian retrovirus, causes myelocytomas, carcinomas, sarcomas and lymphomas, and belongs to a family of oncogenes conserved throughout evolution. In humans, the family consists of five genes: c-Myc, N-Myc, R-Myc, L-Myc and B-Myc. Amplification of the N-Myc gene has been found in human neuroblastomas and cell lines. Its amplification correlates well with the stage of neuroblastoma disease. Immunological studies have shown that the human N-Myc gene encodes a nuclear phosphoprotein that exhibits relatively short (30 min) half life in vivo. The prototype member of the family, c-Myc p67, binds DNA in a sequence-specific manner subsequent to dimerization with a second basic region helix-loop-helix leucine zipper motif protein, designated Max.

UniProt: P04198