OTX2 antibody (full length)

Catalog No. ABIN7878767

This Mouse Monoclonal antibody specifically detects OTX2 in ELISA and FACS. It exhibits reactivity toward Human.

Quick Overview for OTX2 antibody (full length) (ABIN7878767)

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This OTX2 antibody is un-conjugated

Application: ELISA, Flow Cytometry (FACS)

Clone: PCRP-OTX2-1E10

Product Details anti-OTX2 Antibody

Binding Specificity: full length

Purpose: OTX2 Antibody / Orthodenticle homolog 2

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length OTX2 protein was used as the immunogen for the OTX2 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the OTX2 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the OTX2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for OTX2

Target: OTX2 (Orthodenticle Homeobox 2 (OTX2))

Alternative Name: OTX2

Background: Transcription factors OTX1 and OTX2, two murine homologs of the Drosophila orthodenticle (OTD), show a limited amino acid sequence divergence. OTX1 and OTX2 play an important role during early and later events required for proper brain development in that they are involved in the processes of induction, specification and regionalization of the brain. OTX1 is involved in corticogenesis, sensory organ development and pituitary functions, while OTX2 is necessary earlier in development, for the correct anterior neural plate specification and organization of the primitive streak. OTX2 is also required in the early specification of the neuroectoderm, which is destined to become the fore-midbrain, and both OTX1 and OTX2 co-operate in patterning the developing brain through a dosage-dependent mechanism. A molecular mechanism depending on a precise threshold of OTX proteins is necessary for the correct positioning of the isthmic region and for anterior brain patterning. The genes which encode OTX1 and OTX2 map to human chromosomes 2p13 and 14q22.3, respectively.

UniProt: P32243

Pathways: Dopaminergic Neurogenesis