Recombinant Retinoblastoma Protein (Rb) antibody (full length)

Catalog No. ABIN7878913

The Rabbit Monoclonal anti-Retinoblastoma Protein (Rb) antibody (Clone RB1-7080R) (ABIN7878913) specifically detects Retinoblastoma Protein (Rb) in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant Retinoblastoma Protein (Rb) antibody (full length) (ABIN7878913)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Retinoblastoma Protein (Rb) antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB1-7080R

Product Details anti-Retinoblastoma Protein (Rb) Antibody

Binding Specificity: full length

Purpose: Recombinant Retinoblastoma Antibody

Purification: Protein A/G affinity

Immunogen: Recombinant human full-length protein was used as the immunogen for the recombinant Retinoblastoma antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant Retinoblastoma antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the recombinant Retinoblastoma antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Retinoblastoma Protein (Rb)

Target: Retinoblastoma Protein (Rb) (Rb Protein) (Retinoblastoma Protein (Rb Protein))

Alternative Name: Retinoblastoma

Background: Recognizes a 105 kDa phosphoprotein, identified as retinoblastoma (Rb) gene product. Its epitope is localized between aa 703-772. It shows no cross reaction with p107 or p130. It specifically stains the nuclei of BT-20 cells and primary human foreskin fibroblast (HFF) cells. It does not stain the Rb-negative BT549 cells. It reacts with the hyperphosphorylated as well as the un (under) phosphorylated form of the Rb protein. Retinoblastoma gene product plays a key role in cell cycle control. It has been identified as a tumor suppressor gene whose loss of its function leads to tumor development. It is widely expressed in a variety of human tissues including breast, esophageal, squamous cell and cervical carcinoma.

UniProt: P06400

Pathways: Mitotic G1-G1/S Phases