Spastin antibody (full length)

Catalog No. ABIN7879070

This Mouse Monoclonal antibody specifically detects Spastin in WB and IF. It exhibits reactivity toward Mouse, Rat and Human.

Quick Overview for Spastin antibody (full length) (ABIN7879070)

Target: Spastin (SPAST)

Reactivity: Mouse, Rat, Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Spastin antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: Sp 6C6

Product Details anti-Spastin Antibody

Binding Specificity: full length

Purpose: Spastin Antibody

Purification: Protein G affinity chromatography

Immunogen: Recombinant full length human Spastin protein was used as the immunogen for the Spastin antibody.

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal dilution of the Spastin antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the Spastin antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for Spastin

Target: Spastin (SPAST)

Alternative Name: Spastin

Background: The AAA protein family members share an ATPase domain and have roles in various cellular processes including intracellular motility, membrane trafficking, proteolysis, protein folding and organelle biogenesis. Spastin, a member of the AAA protein family, is a 616 amino acid protein and is involved in the function or assembly of nuclear protein complexes. The Spastin protein is expressed ubiquitously and localizes to the nucleus and the cytoplasm, where it may also be involved in microtubule dynamics. Mutations in the Spastin gene (SPAST, SPG4) cause the most common form of spastic paraplegia 4, an autosomal dominant form of hereditary spastic paraplegia (HSP). HSPs comprise a group of inherited neurological disorders characterized by spastic lower extremity weakness due to a length-dependent, retrograde axonopathy of corticospinal motor neurons. SPAST-specific mutations account for approximately 40 % of all autosomal dominant HSPs.

Pathways: Microtubule Dynamics, M Phase, Regulation of Cell Size