TOP1MT antibody (full length)

Catalog No. ABIN7879158

The Mouse Monoclonal anti-TOP1MT antibody is suitable to detect TOP1MT in samples from Human. It has been validated for IHC (p).

Quick Overview for TOP1MT antibody (full length) (ABIN7879158)

Target: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TOP1MT antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: TOP1MT-568

Product Details anti-TOP1MT Antibody

Binding Specificity: full length

Purpose: TOP1MT Antibody / Topoisomerase I mitochondrial

Purification: Protein G affinity chromatography

Immunogen: Recombinant full-length human protein was used as the immunogen for the TOP1MT antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the TOP1MT antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.2 mg/mL

Buffer: 0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store the TOP1MT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TOP1MT

Target: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Alternative Name: TOP1MT

Background: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

UniProt: Q969P6