Recombinant TOP1MT antibody (full length)

Catalog No. ABIN7879162

The Rabbit Monoclonal anti-TOP1MT antibody (Clone TOP1MT-2883R) (ABIN7879162) specifically detects TOP1MT in IHC (p). The antibody is reactive with Human samples.

Quick Overview for Recombinant TOP1MT antibody (full length) (ABIN7879162)

Target: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This TOP1MT antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: TOP1MT-2883R

Product Details anti-TOP1MT Antibody

Binding Specificity: full length

Purpose: Recombinant TOP1MT Antibody (azide and preservative free)

Purification: Protein A affinity chromatography

Immunogen: Recombinant full-length human protein was used as the immunogen for the recombinant TOP1MT antibody.

Isotype: IgG, kappa

Application Details

Application Notes: Optimal dilution of the recombinant TOP1MT antibody should be determined by the researcher.

1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: 4 °C,-20 °C

Storage Comment: Store the recombinant TOP1MT antibody at 2-8oC (with azide) or aliquot and store at -20oC or colder (without azide).

Target Details for TOP1MT

Target: TOP1MT (Topoisomerase (DNA) I, Mitochondrial (TOP1MT))

Alternative Name: TOP1MT

Background: DNA topoisomerases are nuclear enzymes that regulate the topological structure of DNA in eukaryotic cells by transiently breaking and rejoining DNA strands. Due to their roles in DNA replication, recombination, and transcription, DNA topoisomerases have been identified as targets of numerous anticancer drugs. Mitochondrial Topo I (DNA topoisomerase I, mitochondrial) is a 601 amino acid protein that primarily acts to relieve DNA strain that may occur during duplication of mitochondrial DNA. As a type IB topoisomerase, mitochondrial Topo I requires a divalent metal, either, calcium or magnesium, as well as an alkaline pH for optimal activity.

UniProt: Q969P6