MSK1 antibody (pSer376)

Catalog No. ABIN7879734

The Rabbit Monoclonal anti-MSK1 antibody is suitable to detect MSK1 in samples from Human. It has been validated for WB.

Quick Overview for MSK1 antibody (pSer376) (ABIN7879734)

Target: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This MSK1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: FCF-18

Product Details anti-MSK1 Antibody

Binding Specificity: pSer376

Purpose: Phospho-MSK1 Antibody (pS376)

Purification: Affinity purified

Immunogen: A synthetic peptide specific to human MSK1 / RPS6KA5 (surrounding pS376) was used as the immunogen for the phospho-MSK1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the phospho-MSK1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the phospho-MSK1 antibody at -20oC.

Target Details for MSK1

Target: MSK1 (RPS6KA5) (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 5 (RPS6KA5))

Alternative Name: MSK1

Background: Mitogen and stress activated protein kinase 1,' also called RPS6KA5, is a serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factors RELA, STAT3 and ETV1/ER81, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. [UniProt]

UniProt: O75582

Pathways: MAPK Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades