CDK7 antibody (pThr170)

Catalog No. ABIN7879782

The Rabbit Polyclonal anti-CDK7 antibody is suitable to detect CDK7 in samples from Human and Mouse. It has been validated for WB, IHC (p) and DB.

Quick Overview for CDK7 antibody (pThr170) (ABIN7879782)

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CDK7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Dot Blot (DB)

Product Details anti-CDK7 Antibody

Binding Specificity: pThr170

Purpose: Phospho-CDK7 Antibody (pT170)

Purification: Antigen affinity purified

Immunogen: A synthetic peptide corresponding the amino acids surrounding phosphorylated T170 was used as the immunogen for the phosph-CDK7 antibody.

Isotype: Ig Fraction

Application Details

Application Notes: The stated application concentrations are suggested starting points. Titration of the phospho-CDK7 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Aliquot the phospho-CDK7 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for CDK7

Target: CDK7 (Cyclin-Dependent Kinase 7 (CDK7))

Alternative Name: CDK7

Background: The protein encoded by this gene is a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are highly similar to the gene products of Saccharomyces cerevisiae cdc28, and Schizosaccharomyces pombe cdc2, and are known to be important regulators of cell cycle progression. This protein forms a trimeric complex with cyclin H and MAT1, which functions as a Cdk-activating kinase (CAK). It is an essential component of the transcription factor TFIIH, that is involved in transcription initiation and DNA repair. This protein is thought to serve as a direct link between the regulation of transcription and the cell cycle.

UniProt: P50613

Pathways: Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, M Phase