Recombinant ATE1 antibody

Catalog No. ABIN7880001

The Rabbit Monoclonal anti-ATE1 antibody is suitable to detect ATE1 in samples from Human, Mouse and Rat. It has been validated for WB and IHC.

Quick Overview for Recombinant ATE1 antibody (ABIN7880001)

Target: ATE1 (Arginyltransferase 1 (ATE1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ATE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: 30A62

Product Details anti-ATE1 Antibody

Purpose: ATE1 Antibody / Arginyl transferase 1

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human ATE1 was used as the immunogen for the ATE1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the ATE1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the ATE1 antibody at -20oC.

Target Details for ATE1

Target: ATE1 (Arginyltransferase 1 (ATE1))

Alternative Name: ATE1

Background: ATE1 antibody detects arginyl transferase 1, an enzyme encoded by the ATE1 gene. ATE1 catalyzes the post translational addition of arginine to the N terminus of proteins, a modification known as arginylation. This modification regulates protein stability, localization, and function. Arginylation influences multiple biological processes including cytoskeletal organization, cardiovascular development, and stress responses.

ATE1 antibody is widely applied in protein modification research, developmental biology, and cell signaling. Arginylation is part of the N end rule pathway of protein degradation, where the identity of the N terminal residue determines protein half life. By detecting ATE1, researchers can study how this enzyme contributes to protein turnover, quality control, and cellular adaptation.

Western blotting with ATE1 antibody detects enzyme expression in heart, liver, and brain. Immunohistochemistry maps ATE1 in tissues undergoing development or stress, while immunofluorescence reveals cytoplasmic localization and associations with cytoskeletal structures. These applications provide valuable tools for understanding protein arginylation across biological systems.

ATE1 plays a critical role in cardiovascular biology. Knockout studies in mice demonstrate that ATE1 is essential for heart development and angiogenesis. Loss of arginylation disrupts actin filament organization and cellular migration. By applying ATE1 antibody, scientists can explore how arginylation shapes cardiovascular and developmental pathways.

In cell biology, ATE1 regulates actin and other cytoskeletal proteins, modulating cell adhesion and motility. Arginylation also affects metabolic enzymes and stress response proteins, linking ATE1 to adaptation under hypoxia or oxidative stress. Dysregulation of ATE1 has been associated with cancer progression, where altered protein stability influences tumor growth and metastasis. The antibody thus supports both basic and translational research.

ATE1 also contributes to neurological development and function. Arginylation of synaptic proteins influences plasticity and neuronal survival. This expands the relevance of ATE1 antibody to studies in neurobiology and neurodegenerative disease. Ongoing research highlights ATE1 as a potential therapeutic target for modulating protein stability and cellular adaptation.

ATE1 antibody from NSJ Bioreagents provides reliable specificity for analyzing arginyl transferase 1. Its strong performance ensures accurate detection of this enzyme in developmental, cancer, and neurobiological contexts.

UniProt: O95260

Pathways: SARS-CoV-2 Protein Interactome