Cathepsin D antibody

Catalog No. ABIN7880202

The Mouse Monoclonal anti-Cathepsin D antibody is suitable to detect Cathepsin D in samples from Human. It has been validated for WB and IHC (p).

Quick Overview for Cathepsin D antibody (ABIN7880202)

Target: Cathepsin D (CTSD)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Cathepsin D antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Grade: Carrier-free

Clone: CTSD-4497

Product Details anti-Cathepsin D Antibody

Purpose: CTSD Antibody / Cathepsin D (azide and preservative free)

Purification: Protein A/G affinity

Immunogen: Purified His-tagged CTSD protein was used as the immunogen for the CTSD antibody.

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal dilution of the CTSD antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Preservative: Azide free

Storage: -20 °C

Storage Comment: Aliquot the CTSD antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Target Details for Cathepsin D

Target: Cathepsin D (CTSD)

Alternative Name: CTSD

Background: Cathepsin D is a ubiquitously expressed lysosomal aspartyl protease involved in the normal degradation of proteins. It is synthesized as an inactive 43 kDa preprocathepsin D that is cleaved and glycosylated to form a 46 kDa procathepsin D and then further cleaved to produce 28 kDa and 15 kDa subunits (heavy and light chains, respectively). Cathepsin D exhibits pepsin-like activity and plays a role in protein turnover and in the proteolytic activation of hormones and growth factors. Mutations in this gene play a causal role in neuronal ceroid lipofuscinosis-10 and may be involved in the pathogenesis of several other diseases, including breast cancer and possibly Alzheimers disease.

UniProt: P07339

Pathways: Peptide Hormone Metabolism