CD46 antibody

Catalog No. ABIN7880327

This Mouse Monoclonal antibody specifically detects CD46 in WB, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for CD46 antibody (ABIN7880327)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: 9E9-

Product Details anti-CD46 Antibody

Purpose: CD46 Antibody

Sequence: YRYLQRRKKK GTYLTDETHR EVKFTSL

Purification: Affinity purified

Immunogen: Amino acids YRYLQRRKKKGTYLTDETHREVKFTSL from the human protein were used as the immunogen for the CD46 antibody.

Isotype: IgG1

Application Details

Application Notes: Optimal dilution of the CD46 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CD46 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CD46

Target: CD46

Alternative Name: CD46

Background: CD46 complement regulatory protein also known as CD46 (cluster of differentiation 46) and Membrane Cofactor Protein is a protein which in humans is encoded by the CD46 gene. The protein encoded by this gene is a type I membrane protein and is a regulatory part of the complement system. And the encoded protein has cofactor activity for inactivation of complement components C3b and C4b by serum factor I, which protects the host cell from damage by complement. In addition, the encoded protein can act as a receptor for the Edmonston strain of measles virus, human herpesvirus-6, and type IV pili of pathogenic Neisseria. Finally, the protein encoded by this gene may be involved in the fusion of the spermatozoa with the oocyte during fertilization. Mutations at this locus have been associated with susceptibility to hemolytic uremic syndrome. Alternatively spliced transcript variants encoding different isoforms have been described.

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization