Recombinant CHMP2B antibody

Catalog No. ABIN7880390

This Rabbit Monoclonal antibody specifically detects CHMP2B in WB, IHC (p) and IP. It exhibits reactivity toward Human.

Quick Overview for Recombinant CHMP2B antibody (ABIN7880390)

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CHMP2B antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP)

Clone: 25C36

Product Details anti-CHMP2B Antibody

Purpose: CHMP2B Antibody / Charged multivesicular body protein 2b

Purification: Affinity chromatography

Immunogen: A peptide sequence specific to Charged multivesicular body protein 2b protein was used as the immunogen for the CHMP2B antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CHMP2B antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Antibody in PBS with 0.02 % sodium azide, 50 % glycerol and 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: After reconstitution, the CHMP2B antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Target Details for CHMP2B

Target: CHMP2B (Charged Multivesicular Body Protein 2B (CHMP2B))

Alternative Name: CHMP2B

Background: Charged multivesicular body protein 2b (CHMP2B) is a component of the endosomal sorting complex required for transport III (ESCRT-III). It plays a critical role in multivesicular body formation, membrane fission, and the sorting of ubiquitinated proteins for lysosomal degradation. CHMP2B is essential for maintaining proper endosomal trafficking and cellular protein homeostasis.

Mutations in CHMP2B have been linked to neurodegenerative disorders, including frontotemporal dementia and amyotrophic lateral sclerosis. Research on CHMP2B helps elucidate mechanisms of vesicular transport, neuronal maintenance, and protein quality control, making it relevant in both basic and disease-focused studies.

Using a high-quality CHMP2B antibody enables accurate detection in applications such as western blot, immunohistochemistry, and immunofluorescence. A CHMP2B antibody from NSJ Bioreagents provides reliable and reproducible performance for studies in membrane trafficking, neurodegeneration, and cellular signaling. Selecting the right CHMP2B antibody is essential for obtaining consistent and meaningful results.

UniProt: Q9UQN3