Recombinant CDSE1 antibody

Catalog No. ABIN7880470

The Rabbit Monoclonal anti-CDSE1 antibody (Clone 30C82) (ABIN7880470) specifically detects CDSE1 in WB, IP, IHC, IF and ICC. The antibody is reactive with Human, Mouse and Rat samples.

Quick Overview for Recombinant CDSE1 antibody (ABIN7880470)

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CDSE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunocytochemistry (ICC)

Clone: 30C82

Product Details anti-CDSE1 Antibody

Purpose: CSDE1 Antibody / Cold shock domain containing E1

Purification: Affinity-chromatography

Immunogen: A synthesized peptide derived from human CSDE1 was used as the immunogen for the CSDE1 antibody.

Isotype: IgG

Application Details

Application Notes: Optimal dilution of the CSDE1 antibody should be determined by the researcher.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol, 0.4-0.5 mg/mL BSA

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store the CSDE1 antibody at -20oC.

Target Details for CDSE1

Target: CDSE1 (Cold Shock Domain Containing E1, RNA-Binding (CDSE1))

Alternative Name: CSDE1

Background: CSDE1 antibody detects cold shock domain containing E1, an RNA binding protein encoded by the CSDE1 gene. CSDE1 contains five cold shock domains that mediate single stranded RNA binding, enabling regulation of mRNA stability, splicing, and translation. It associates with ribonucleoprotein complexes and influences the fate of transcripts involved in development, stress response, and tumorigenesis.

CSDE1 antibody is widely applied in RNA biology, cancer research, and developmental studies. CSDE1 promotes internal ribosome entry site (IRES) mediated translation of select mRNAs, enabling protein synthesis during conditions when cap dependent translation is impaired. It also regulates RNA turnover and processing through interactions with RNA binding proteins and decay machinery. By detecting CSDE1, researchers can evaluate how RNA binding proteins integrate post transcriptional control of gene expression.

Western blot assays detect CSDE1 protein bands in cytoplasmic fractions, while immunohistochemistry maps its distribution across epithelial and neuronal tissues. Immunofluorescence highlights punctate localization in ribonucleoprotein granules, consistent with functions in RNA storage and processing. These methods allow detailed characterization of CSDE1 expression and function.

CSDE1 plays important roles in tumorigenesis. In melanoma and other cancers, CSDE1 promotes oncogene expression and suppresses tumor suppressor translation. Elevated CSDE1 levels correlate with tumor progression, invasion, and metastasis. By applying CSDE1 antibody, scientists can investigate how post transcriptional regulation contributes to cancer biology and therapy resistance.

Beyond oncology, CSDE1 is implicated in embryonic development, neuronal differentiation, and stress adaptation. It influences neuronal polarity and axon growth, as well as cellular responses to hypoxia and nutrient deprivation. These broad functions highlight the research value of CSDE1 antibody across multiple biological fields.

CSDE1 antibody from NSJ Bioreagents provides dependable specificity for detecting this RNA binding regulator, supporting reliable analysis of RNA metabolism and translational control.

UniProt: O75534

Pathways: SARS-CoV-2 Protein Interactome